Planet Lean: The Official online magazine of the Lean Global Network
How we made our microbiology lab Covid-ready

How we made our microbiology lab Covid-ready

The Microbiology Lab team
May 18, 2020

FEATURE – When the number of Covid-19 cases skyrocketed in the Italian region of Piedmont, this microbiology lab had to find a way to increase its capacity to process swab tests. Here’s how they did it.


Words: Andrea Rocchetti, Franca Gotta, Roberto Guaschino, Laura Mazzucco, Giacomo Centini, Sara Barooty, Noemi Virto, and Caterina Bianciardi, SS. Antonio e Biagio e Cesare Arrigo hospital, Alessandria - Italy.


At the end of 2018, our hospital – the SS. Antonio e Biagio e Cesare Arrigo hospital (AO AL) in the city of Alessandria, in northern Italy – established a multi-year strategic plan based on the implementation of lean projects in different areas of the organization. As part of this effort, a team of internal lean coaches was created, tasked with developing the lean capabilities of the hospital’s employees and supporting the development of improvement initiatives coming both from the front line and the management team.

The Covid-19 pandemic presented us with a huge challenge. On March 6th, the regional government of the Piedmont region chose the microbiology laboratory in our hospital for the processing of swab tests for the detection of Covid-19 infections. We were aware of the huge spike in demand we were going to experience and realized we had to quickly reorganize our laboratory.

We decided, therefore, to create a dedicated space for the pre-analytical phase of testing, open seven days a week. We completely reengineered our production process to meet the growing demand and guarantee a quick analysis of samples coming from hospitalized patients, but also from patients from the area our laboratory is responsible for (as well as those that couldn’t be processed by other nearby heath authorities and that the regional government asked us to take).

Not only did we have to increase our capacity, but we also had to analyze the process in detail to identify inefficiencies.

Here you can see the different steps in our process:

Process map for the microbiology laboratory

The original process, which was almost entirely manual, required a lot of effort by the administrative staff, especially in the initial steps of cross-referencing and registration, to upload paper-based requests onto the lab’s IT system – with the high risk of making mistakes.

As far as the pre-analytical phase is concerned, we also created a dedicated team of technicians and biologists and managed to find a room that could be used exclusively for aliquoting samples in secondary test tubes to essentially pre-process the swabs and then assign them to the available machines. This is when the pre-analytical phase is complete.

Samples are distributed to two types of machines, each with its own cycle duration and capacity (to start the cobas machine, for example, means waiting to have 94 samples to test – lest we waste reagents), based on where they come from and on priority.

Over the first few weeks of the Covid-19 crisis, the reorganization of the process led to an exponential increase in the number of swab tests we can process – as shown in the graphic below.

The laboratory managed to increase its capacity exponentially

Despite the increased activity, the laboratory has been able to gradually reduce its turn-around time (TAT), except for the week of March 16th, when we didn’t receive the reagents that we needed to process the samples.

As the number of cases went up, the TAT (turn around time) was reduced

We are also planning the implementation of another countermeasure that aims to speed up the classification of patients in our Emergency Room: the instalment of the GeneXpert machine, which is currently capable of processing between two and four samples every 45 minutes. Placing the machine in the ER and making it directly available to ER staff would enable a 24/7 activity cycle and the immediate identification of Covid-19 cases.


THE AUTHORS

Andrea Rocchetti, Laboratory Director; Franca Gotta, Microbiology Lab team; Roberto Guaschino, Director of Transfusion Medicine; Laura Mazzucco, Biologist; Giacomo Centini, General Manager; Sara Barooty, Operations Management; Noemi Virto, Operations Management; and Caterina Bianciardi, Process Engineering Manager.

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